Στη νόσο του Parkinson τα on-off φαινόμενα εμφανίζονται με απότομη και απροειδοποίητη διαταραχή των κινήσεων, έτσι που ο ασθενής να μένει «παγωμένος» και να μην μπορεί να κινηθεί ακόμα παρόλο που καταβάλλει τη μέγιστη δύναμη.
Οι αγωνιστές της ντοπαμίνης είναι μια νέα σειρά φαρμάκων που τελευταία κυκλοφόρησε στην αγορά προκειμένου να βοηθήσει τη θεραπευτική διαδικασία του συνδρόμου του Parkinson.
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